Like many here, I'll repeat that each rider's size/dimensions/posture are different, but regardless, I'll throw in my 2 cents:

I have a 38" waist and a 32" pant inseam. My legs are strong, but not bulky...in other words, I have sort of a wide gait for cycling, and not a very thick set of glute's to complement it. I have a ridiculously, shamefully large collection of cheap saddles at home, and there are two that stick out the most in terms of overall comfort when riding in a more upright position. The Velo Bio:Logic and the PlanetBike Mens A.R.S. 5020. For more upright riding (think flatbars/bullhorns/city/northroad/etc.) these are firm, yet comfortable for someone with such wide sitbone measurements as my own. If you're planning to ride in a more aggressive position (think dropbars, or with a saddle set much higher than the handlebars), I like the PlanetBike Mens A.R.S. 5022 (cue late "arse" jokes), as it doesn't rub my inner thighs as much, while still providing a decent padding for these old sit bones. As always, YMMV.