From when I started riding on a regular basis to what I do now, the thing that made the biggest difference in my sanity and comfort level was this:

Smart route choice.

I initially rode routes that were very similar to what I would have taken if I was on my motorcycle. This was a mistake. With a little forethought and planning, I was able to find routes that were only slightly longer that were much calmer. My anxiety level went way down, and riding to work every day is now fun--the highlight of my day, really. Look for slower, less trafficy roads, and ones that have bike lanes or good shoulders if possible. I don't know what the roads are like near you, but I also have to avoid cobblestones and rough pavement if I can.