I have yet to find a comfortable seat, something that doesn't have me repositioning myself frequently to get rid of discomfort. I've tried numerous seats, I experiment a lot with the seat position, been fitted twice, etc. So I can't offer you any practical advice.

But I can deal with an answer to your question.

Cobb Cycling (saddle makers) recommends pointing the seat to the side. I tried it both right and left for several weeks and couldn't notice any significant difference. Here's the relevant quote (plus some words on tilting your pelvis) from his installation instructions:

If you feel high “pressure” in
your crotch or soft tissue, you
might need to “rotate” the
saddle to relieve this. Most
bike seat post allow for the
rotation to the right or left
side, one direction will feel
much better than the other. It
is possible to rotate the nose
slightly, even on bikes with
non adjustable seat clamps.
Simply hold the node firmly to
one side while tightening the
clamp and it will generally stay
there. Try it, it will be noticeable
right away. It may take
one or two tries to get the seat
nose just right.
Another thing that goes
against normal thinking is that
we often have to raise the
saddle nose to take pressure
o of “Soft Tissue” or the
crotch “nerve bundle”. Raising
the nose will help you rotate
your pelvis and let you slide
back into the natural valley
that is moulded into the seat.
Proper pelvic rotation is a
major key to riding happiness.
Rotating your pelvis forward
will free up your breathing
and bring in the more powerful
back and Glute muscles to
ride with. This may take a little
practice but it is well worth
the trouble. It will open your
diaphragm area for much
improved breathing.


Hope this helps you.