I have at least one weeks worth of wardrobe that I just leave at work. Shirts (6) are laundered every other week and pants (4) once each month. Shoes stay at work. I only carry socks and underwear back and forth on the commute. Yes, it would be a pain to carry a full wardrobe each day. I usually have enough bicycle clothing/rain gear to fill up a pannier in the winter. This time of year is perfect. I can carry everything I need (socks, underwear, wallet, phone, keys) in my jersey pockets.