48/32/22 & 52/39/24 are both requiring you to buy new chainrings , plus the crankset .. & BB..
Now IDK if you can mix cassette cogs you have to accept the sets from the factories, just as well
as wearing out non standard sets and making them up from individual cogs is pricey, once let alone repeatedly.. .
3. Can 105 derailleurs handle this gearing?
I doubt anything but a long cage MTB derailleur can wrap up (52-24) 28t, or (48-22) 26t