I would take a top end carbon frame (custom Parlee/Crumpton or at least Cervelo RCA lol) over a top end Titanium frame.
In addition to being much lighter and stiffer typically, you can have far more complex shaping with carbon. I feel that gives it a design capability advantage.

Titanium looks amazing, rides great, and is durable (at least the non superlight ones).

But I need that weight savings where I live since I'm way overweight in the hills.