I have been riding an ISM Adamo Prologue for over a year. After trying several of the popular saddles and some suggested on this forum, I went with the ISM on the advise of my fitter. The minute I sat on the saddle I noticed the difference and it definitely won out by leaps and bounds over the others I tried. It was the most comfortable saddle I've ridden and it hasn't changed any a year later. I ride daily and put a lot of miles on my bike. Even after 100k+ rides, I don't feel any soreness or irritation from the saddle. I also haven't experienced any perennial numbness since using this saddle.

The only thing you need to make sure you do, if you are mounting the saddle yourself, is to watch their web site video on proper installation. You also need to see their illustration on where you are suppose to sit on the saddle. If you mount it wrong or don't sit on it correctly, it will be very uncomfortable.