If you are comfortable with your bike-the performance gains will be marginal....however comfort is an area which you might be able to improve by leaps and bounds by changing frame materials-carbon fiber or ti or even steel can be more comfortable than Cannondale's Al frame. I had an 03 r3000 and I am now on a litespeed tuscany and it is much more comfortable than the Cdale was for my 47 year old body. Is it any faster-probably NOT. Is it any slower-probably NOT. Am I as beat up after a long ride for me (100km+) DEFINITELY not. My lower back used to hurt bad after a long ride on the Cdale-it doesn't on the litespeed. For a ride as long as you are doing-I would want as comfortable bike as possible that did not sacrifice speed. JMHO.