I actually did that ... well, did half of it, just to get a feel for it. It was the home to halfway part, and all in all, it wasn't bad. One street closing that was easily navigated.
And the week before I drove (sort of) the work to home route (obviously didn't ride on the MUP but followed it closely) and that's probably the easier part of the ride.
I think it's just that "unknown" of how it will go and the lack of a routine for when I arrive at work that has me hesitant.