I have severe RA and take Enbrel, Methotrexate and Meloxicam (mobic)... Helps, while i was waiting to be diagnosed i was on Prednisone for 2.5 years and develloped Type 2 DIabetes...That is why i started cycling...The cycling helps my knees more than anything i have done over the last 10 years...I can pedal and a very nice cadence and do 20 miles i find without ANY joint pain...My muscles now ,,,, LOL yhat's another story...working on that...I tried MSM, Chondroitin and Glucosamine either by themselves or all together with absolutely no results... My rheumatologist said while not really snake oil it is hit or miss in about 75% of his patients...Catching it on time and treating it is the best to prevent real joint damages...