OP might want to install liners in his tires and/or use flat-resistant tires. Removing tire, changing tube, reinstalling tire is a task he might want to avoid, especially if the tire is a tight road tire.
Carry extra cartridges for the CO2 inflator, because it really sucks to run out. I once had two punctures in five minutes because it was dark and raining and I couldn't find the tiny wire embedded in the tire casing. I've also had to go knocking on doors, asking to borrow a bike pump because I ran out of CO2 cartridges.