Joined: Jul 2002
Posts: 40,863
Likes: 3,115
From: Sacramento, California, USA
Bikes: Specialized Tarmac, Canyon Exceed, Specialized Transition, Ellsworth Roots, Ridley Excalibur
FWIW, I like having slightly different cassettes, say a 12-27 for the hills and a 12-23 for the flatlands. As long as you size the chain for the bigger, you shouldn't have any issues.