i commute a few days a week on a trek antelope 800 (which was a hardtail mtn bike on knobby tires) in NYC usually trying to avoid the potholes - on slick tires 26 x 1.5" (nashbar kevlar - cheap) - sure they aren't as fast as the road bike but it does the job. about 16 miles round trip. switching from knobby to slicks based on recommendations here at bikeforums.net. the slicks make a big difference. i've only had one flat - but i couldn't even find a puncture on the tube but replaced it anyway because the tube is like 20 years old.
recently got on a trek fx 7.7 hybrid as my weekend "fun" bike -