When I first really got into road cycling, I went crazy trying to find a comfortable saddle. Looking back, saddle comfort finally came for me about the same time I really started working on my core and flexibility. Now I seem to be fine on any bike, any saddle, at least for a while. I'm sure it's not the magic bullet for every situation, but if you're not already doing dedicated core and flexibility work, I would try that before investing too much in a new saddle.
Recently, I added Tom Danielson's Core Advantage to my workout. So far, so good. It's cycling-specific, so seems worth a try.