This recent study shows that those who take a statin have a reduced capacity for exercise. It can be found at http://psychiatryneurology.net/foren...g-adaptations/.

Abstract
OBJECTIVES:
This study sought to determine if simvastatin impairs exercise training adaptations.

BACKGROUND:
Statins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but it is unclear whether statin use alters adaptations to exercise training.

METHODS:
This study examined the effects of simvastatin on changes in cardiorespiratory fitness and skeletal muscle mitochondrial content in response to aerobic exercise training. Sedentary overweight or obese adults with at least 2 metabolic syndrome risk factors (defined according to National Cholesterol Education Panel Adult Treatment Panel III criteria) were randomized to 12 weeks of aerobic exercise training or to exercise in combination with simvastatin (40 mg/day). The primary outcomes were cardiorespiratory fitness and skeletal muscle (vastus lateralis) mitochondrial content (citrate synthase enzyme activity).

For myself, I had cycled over 4,000 in a year (100 miles a week) but still felt weak and tired and could not lose weight.

As soon as I started taking COQ10 (which counteracts statin's adverse affect on ATP) I felt like a turbocharger had kicked off in my legs. My strength and energy levels improved drastically. My average heart rate jumped nearly 10% as did my average speed -- but despite the increased intensity I no longer felt fatigued for the rest of the day after a ride. And, I started losing weight!

But the cardiologists tell you the "myopathy" from statins is rare: That's probably because of the way they measure it. If you set the threshold high enough, (or measure muscle pain instead of weakness) it will be rare...