What are your goals while riding on this trip? Are you trying to get across country as fast and easy as possible? Or do you want scenic and interesting routes, with more complicated navigation and perhaps more hill climbing?
For instance, the section from Indianapolis to Columbus OH is mostly flat farming country. It does pick up some bike trails around Dayton, though.
A more interesting route is down to Louisville KY, then across KY near Lexington, and cross to Ohio at Maysville KY and northeast to Chillicothe OH. You'd see historic Ohio River towns, bluegrass horse farms, and many, many 300 foot climbs and descents along the way.
Almost anywhere in the SW Ohio area, try to take nearby local roads instead of US highways. They are just about all paved, and have very little traffic.