I haven't ever biked it but I've driven it many times.

Wickenburg to Parker to 29 Palms? That's a lot of empty desert and adds some miles.

If you pick up I-10 at the US-60 truck stop and get off it at Blythe, you're only on I-10 for 30-some miles. That stretch of US 60 from Wickenburg was resurfaced seven or eight years ago and should be nice to bike on.