The problem with the freehubs is while they solve the non-existent/easily engineered problem of axle breakage, they pick up either a ton of weight/cost/or shell breakage.

Another problem is that if you want to run practical 8s or something, you still end up with a spoke rigging angle set up for whatever cassette nonsense is current or expected for racers. When I built out my White hubs the dish looked like a straight line, on the centerline. Whatever it is, it will work fine, but I would certainly worry more about spokes on that puppy than with a freewheel. Unless you really need those cassette spacings and want to use the shift schedule to use them, what's the point. Another tech one would have to bite off would be brifters, the constant shifting is going to determine your position, and your gear there. So I guess if you want to ride the hoods across country changing gears like a rat on crack, you have your set-up with the new triples.