Originally Posted by
Barrettscv
Try intermodal. Use the bike on the safest section and use the car or public transit where the traffic or roadways are less bike-friendly.
This works for me since my 65 mile commute is served by mainline commuter rail on the heavily traveled San Diego/Los Angeles corridor. It may be more of a challenge for OP if his options are limited to inter-city bus with a travel time of 3-4x commuter rail. My commute in the morning is only 20 min longer than driving and is the same in the afternoon, except Friday, where the train is faster than crawling along on I-5.