I have an S-Works Tarmac and absolutely love it. Descending and climbing are where it really shines. The Cannondale evo is very interesting and, my friend who has one (evo hi-mod) loves it. I wish it had a slightly taller head tube as the "comfort" bikes like the Roubaix typically do not descend really well (as mentioned above by Ti). Given the comfort of the modern race bikes like the Tarmac and EVO (and probably the newer Madone), I don't think the "comfort" bikes offer much advantage unless you travel on rougher roads (including dirt/gravel). Frankly, I'm considering one for exactly this purpose. Greenways, gravel and dirt, fond events, etc. But club rides, road events, etc the standard race geo bikes do just fine - handling and comfort.