I did soooooooo much research on this subject. At the onset, my instincts told me I wanted a 2 wheel trailer..Burley Nomad, for my 1500 mile tour, but I was prepared to listen to the loudest voice on this forum. As it turns out, it came down mainly to preference, rather than any definate black and white answer. So, I bought the Nomad, and I am now on mile 823, of the aformentioned tour. I love my trailer. I had to put tire liners on the wheels, as they punctured easily, but that is it. I travelled for a while with a guy who had a BOB, and he was envious of my 2 wheeler!! However, the BOB can support the bike and keep it upright, when you park it, which is the only thing I don't have with my Burley. Otherwise, I couldn't want more from it.
Anywho, go with what you want, or think you want, you'll probably be right.
Good luck.
Helen