Kysrium wheels will probably make you slower on the flats and slightly faster on the climbs. Although somewhat light, they are some of the least aero wheels ever.

New components? You can probably save 1-2 lbs which will make you 0.5%-1% faster on steep climbs and 0% difference on flats.

New frameset? Save 0.5-1lb and make you < 0.5% faster on steep hills.