Friend and I rode from Cassville to Jane, MO ( just across the line from Bentonville). Here's the route we took.
https://www.crazyguyonabike.com/doc/..._id=91691&v=8B
I'd stay off hwy 86 between hwy 65 and Cassville. Lots of traffic, rumble strips force you to stay off shoulder of road, very hilly.