I chose the Anthem because of the suspension design. It is first class and has a strong following already.

Smallish builders such as Serotta, Cinelli, Moots, etal, would be considered off the list due to the obvious limited availability status which naturally gives them "collector" status.

LeMond bikes before Trek are already considered as collectible by many. After Trek, not so much.

Caad 9 makes sense in that it was last of USA built and a great ride, but the Caad10 because of the ride quality engineered into it. It changed how alum frames are designed.

Never thought of the Orca as a great frame, but it does look nice and probably should be included.

SL4 frames really upped the ante for carbon designs utilizing oversized down tube diameters. For this reason I see them on the list. Much like the original Cdale frames are now classics due to the oversized alum tubes which created the stiffness of steel in an alum bike.

Never thought of the Venge as a game changer, but the McLaren link may put it on the list.

Off road, I would certainly pick the Giant over a Colnago!