My bike fit seems to have reached a point where I don't change much any more. In the past, when I was making weekly changes, I used a white out pen to mark the seat post, saddle tilt, bars or whatever was being changed. Those marks are still there so that if I try a different setting, I can easily get back to a previous setting. Just recently, on a ride, the saddle was causing some slight discomfort. Usually the saddle is not noticed at all. After returning home at the end of the ride, I inspected the saddle it it had rotated downward in front by a tiny bit. This was easy to see due to the white line on the rail housing.

I also have a troublesome right knee. To date my treatment has been knee exercises, particularly lateral movements because riding provides plenty of fore and aft exercise. If the knee acts up, I step up the exercises. This might not work for everyone but being as strong as possible is always good and, so far, it works.