My experience with Adventure Cycling maps is that they're almost always sufficiently detailed to follow easily, except for that one time in Charlottesville. Urban maps are often easier than rural (e.g., turn right at Suchandsuch Road, unmarked). They have two sets of directions, one for northbound and one for southbound (for the Atlantic Coast route). You'll have to check when you run off a fold to make sure you ge tthe next one in sequence regardless of the direction you're going.
Before you ask a general question like "Is there a great route?" it might be worthwhile to decide what parameters make a route great. Ease of access to support services (motels, B&Bs, stores)? Takes you right by tourist attractoins? Takes you through great scenery? Takes you down very low trafficed routes? Stays on well paved roads? Unfortunately, "all of the above" only exists between sunrise and 8:30 am Saturday and Sunday mornings.