I love my Domane 5.2 (ultegra 6800 11spd). I ride a lot on bumpy, "noisy" roads in the country and the ride is smoother with the Domane over my aluminum Orbea. Less road buzz. A subtle thing but something I notice after long rides. It climbs better than the Orbea. Descending is great; I know where the bike is going and the new ultegra brakes are awesome.
I really like the Bontrager tires. I haven't hesitated to take the bike on gravel roads. I was thinking of going tubeless but I probably will wait until I need to replace the tires.
If you get a Domane, be sure and get the Trek Care plan. It will more than pay for itself because it covers replacement parts like chains, cassettes, etc.