Thanks for everybody's great points and discussion about the Domane. Went back to the LBS to demo the Domane 4.3, 4.7 and 5.2 with good news and bad news. First the bad news, it appears the Domane 4.3's are all sold out until mid summer when the new 105's 11 speed become available. That narrows the choice to the 4.7 and 5.2. I couldn't believe it, but the 5.2 was a lot smoother on the pavement and had a much better feel compared to the 4.7. I've made an appointment for Friday to take the 5.2 out for a 30-45 minute ride with my pedals and shoes and more of my normal set-up. I'm still struggling to spend this much on a bike even though it will last for many years to come.