Chainline is set by the crank/BB and the frame would not affect this - excepting some oddball [no-dish] frames and the like. You're putting a road bike crank into a road bike. Clearance should almost never be an issue with an external-type crankset, as there are not multiple spindle lengths to choose from. The spindle is part of the crank itself.

I've put external style cranks on a couple of bikes that were from the square taper days. Admittedly a small sample of 2, but ran into zero issues - besides needing new tools.