Just put on 60mm Big Apples (26x2.35) for an upcoming trip from DC to PGH. Run them at 35-40 psi. I occasionally ride with 700x35 tires on my daily commute on the C&O, and certainly wouldn't want to ride 184.5 miles on them.
Hoping the tropical storm stays away. Rode a couple years ago during a hurricane and wouldn't want to try that again. The towpath was impassable, and had to take to the very hilly roads.