Agree with Carbonfiberboy: if you're sitting on the nose of the saddle you either have 1) the wrong saddle, or 2) serious fit problems. Different saddles, different shorts, fancy creams, and all the rest aren't going to matter much if you're sitting on the wrong part of the saddle...

I would attack the position problem before doing anything else. If you start out sitting on the back of the saddle and tend to slide toward the nose, then it may be necessary to tilt the nose up a bit. If you're always sitting on the nose of the saddle, trying pushing the saddle toward the front of the bike. If you can't get it far enough forward, you might need a zero-offset seatpost or in extreme cases a different frame. If you've never had a professional bike fit, it might not be a bad idea to invest in one. I've been riding for quite a while and have my fit dialed in pretty well, but a professional fitter made a few small tweaks to my setup that resulted in some noticeable improvements to comfort especially on longer rides.