I'm 6' 260-285...
I was breaking spokes w/ a 40, even after rebuilt by good mechanic.
Always drive side.
I had a bike builder (mostly high end mountain bikes) build up a pw 48 spoke with velocity chukkers... over 3k miles and still dead true, even with some of the stupid things I've done. Once I accidentally took it airborne at about 20, with a decent load on the rear rack. Another time off a curb, slow but still sounded pretty hard. Low on blood sugar I can really mess up good.
They may not be light, but I know they always get me home.
With my old bike, I once had a front cone seize up on me about 10 miles from home. Out of water, over 100 degrees, I was not comfortable the next day...
Sometimes, nothing succeeds like excess.