The tricky thing about saddle comfort (or discomfort) is that everything effects everything else. A minute amount of saddle tilt can effect hand pressure on the bars and hand pressure can effect saddle pressure. A fitter cyclist pedals with more force which unloads saddle pressure. The handle bar even or lower than the saddle has the cyclist leaning further forward able to press the pedals with more force that unloads the seat pressure.

Like yourself, early on I despaired for finding saddle comfort but eventually did find it. My longest rides these days are 50 to 60 miles and the saddle is only a problem if I've not been riding much such as Spring after being mostly off the bike during the snow months. This points to another issue - that there is a certain amount breaking in of the butt involved AKA as time in the saddle. Good luck and stay with it.