So I finally did my first major modification of my Brompton - of any bike ever really - switching out the 6-speed and putting in the 2-speed wheel.
I have left all the cables and right shifter in but the weight difference is already pretty noticeable. The bike feels notably lighter but the 44Tx12-16T (am I doing it right) makes it tough to start on anywhere but flattish ground.
I'll need a lower first gear if I'm really going to enjoy the 2-speed - the bike may be slower overall but I'd be more confident of tackling hills and slopes. I have purchased a Shimano 105 39T (130mm BCD) and plan to install it this weekend.