Originally Posted by
rpenmanparker
No, the main loss of air is to fill up the pump hose between the tube valve and the gauge. Even if you reconnect the pump right after filling the tire, you will see 10-20 psi loss depending upon (drum roll please

) how long your hose is. I guess that means some guys will see more air loss than others.
Beat me to it. I don't go more than two days between rides unless I fill up the tires anyway.
Oh! If you fill up tires with a CO2 cartridge, expect the tires to actually deflate faster. There some scientific mumbo-jumbo about the permeability of tubes and CO2 that I really don't understand, but it seems to be very true.