My wife and I also live at sea level + 15'. We are going on our first backpack in the high Sierras in a few weeks, so we'll be going from sea level to 10,000' in 2 days: one on the bus and one on foot. From previous climbing adventures, we know that my wife does not do well at altitude. We've been thinking Diamox. However . . .

I'm an inveterate researcher. I've used Hammer's Race Day Boost a few times for RAMROD and the like. It works. It happens that the active ingredient, sodium phosphate, has been tested successfully as an altitude adaptogen. Additionally, Acetyl-L-Carnitine and N-Acetyl Cysteine have also been lab tested and found to work as adaptogens.

This site:
Mountain Might, Altitude Training, High Altitude Training
has some good information about acclimatization techniques, etc. They also sell it in a bottle at a pretty high price.

Anyway, we're going to give the chemical method a try when we hike up to Camp Muir (10,000') at the end of July and spend a couple days there. If I still have two brain cells to rub together, I may remember to post the results, if any.