My knee was aching and all my saddle positions were where they were "supposed" to be. I slid the saddle forward about an inch and all the discomfort went away. Don't go entirely by the charts. Make small adjustments and see how you feel. If it is better go a little further till it is fixed if its worse go the other way. I takes me about a dozen rides to get a bike dialed in to the maximum comfort level. I start at the suggested positions and work on the seat first then the bars/stem then the seat again. As you adjust the fore and aft position the angle will need adjustment too.