A couple of months ago I had my front go flat and I stupidly decided to take a corner BEFORE stopping to change it (in my defense, I only realized it was flat about 2 seconds before the turn). I ate it and got a good case of road rash.

That didn't stop me though, I just changed the tire, brushed the gravel out of my wounds and kept riding.

What stopped me was that my RD hanger was bent and when I downshifted a few miles later, it pushed the RD into the spokes at about 20 MPH. It immediately ripped the RD off the hanger, twisted it around a few times mangling the chain, threw the chain between the cassette and the spokes mangling the spokes, then the RD wedged between the spokes and the frame, instantly locking the rear wheel. Luckily I stopped without falling.

I called for a bailout.

I did start walking towards home anyway though, because the mosquitoes were brutal standing there and I had to walk with my bike over my (still bloody) shoulder to try to get away from them.