The question is why not? If you use a trailer, absolutely.

If you want to mount panniers, the main problem is that the chain stays are not as long as a conventional touring bike. That's not a problem if you do light touring camping with bags mounted on the frame. If you do full panniers and a rack, then I'd think about getting a little longer rack and rear bags that are not too wide so you don't have heel strike issues.

That's typically (but not always) the issue on touring on a bike that is not designed for touring. The advantage of a somewhat shorter wheelbase is that the bike is a bit more responsive when it is not loaded.

Certainly the clearance for generous tires is a plus on the Straggler.

The biggest problem you will have is that the stock gearing is less than ideal with a 46/36 crank. Not a problem if you build the bike from a frame. Or you could replace that crank with a double that goes really low like 46/30 crank from velo orange. The 30 inner is not ideal but it is better than the stock 36 tooth inner. Another possibility would be to go with a salsa vaya. It doesn't have the best triple for touring either. The shimano 130/74 triple Salsa uses plays nicely with shimano brifters but it is not, IMHO, low enough for fully loaded touring). But if you don't mind the expense of building a bike from a frame, this could work. Soma makes a monster cross; the Velo Orange Camargue is another possibility.