I have BPH and take meds to shrink it. The microwave prostate burn helped incrementally on flow and knocked PSA's down to less than 2. I was using SMP saddles (not the $300 ones) but started to get blood in the urine once rides approached 70 to 100 miles. I went back to the Selle Italia Max Flights that I used to use. They have much higher density foam with the same cutouts as the SMP's and are much more comfortable for me over longer distances. Saddle selection is something each rider must determine for themselves, sometimes at great cost. I take blood thinners so the enlarged prostate will impinge on other body parts during cycling to cause bleeding if the saddle doesn't fit well and is not at the right angle and height. My Urologist doesn't believe there is a significant connection between cycling and Prostate Cancer.