Once again, I am trying to get to work on my long-delayed new wheelset project and would like to order parts by Mon AM before I lose my focus

At present am 160 lbs, vary between 150-165...depending, use my fixed bike as a 1-gear road bike, it is flat here, road surface conditions can be problematic but no huge potholes, am a spinner, try to fight weight-weenie tendencies but they are always lurking, so...

Dare I try doing 20/24 spoke wheels? Rims ala Kinlin XR-200 (or 270 if anyone persuades me to be slightly more logical) with low flange hubs?

Or would it be all that much stronger/safer to go with 24/28?