Absolutely! It kept me off a bicycle for over a decade!

Of course, these were the days before grooved and cut-out seats. I had never heard of anyone else getting numbed nethers, so I used a gel seat with a gel cover (which probably put even more pressure where it shouldn't have).

At the time, I thought I was just built funny.

Now I just make sure my "sit-bones" take most of the weight and all is well.