Originally Posted by Brian Ratliff

Sure. I've got the "medium/classic" prius; a bike fits nicely with the back seats folded down. No need to remove wheels. If you remove the front wheel, you can get one of the rear seats back. If you remove both wheels, you can probably fit it without folding seats, but I've never tried it. The "big" prius should be better. I don't think the "small" prius will take a bike without removing wheels, but I've never seen the inside of one.