Other than some quality issues with specific rims (applies to both symmetric and asymmetric rims) there's no reason not to use an asymmetric to reduce the effects of hub asymmetry.
They build the same as any rim so no sweat there. As far as the spoke length calculation goes, the offset factors into the CTF distance, because you're actually looking for the HTF (spoke hole, to flange) distance. It isn't critical because CTF errors only affect spoke length to the extent of 1mm for every 10mm of CTF error.
If you want to be a purist, you can add/subtract the offset distance to the center of the rim form the respective CTF specs to get the HTF and use that in your spoke calculator.
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Last edited by FBinNY; 11-05-14 at 09:56 PM.