When I zeroed in on a final decision after many test rides, of many different bikes it came down to either a Domane or a Madone. I'm 5'7" with slightly shorter than avg. leg length. The shop had me riding 52's. I was liking the feel of the Madone better and both were set up at the same basic locations for stem and seat height. Thank goodness one of the guys at the shop saw me ride by and told the salesperson to put me on a 54. I didn't know, it felt better than anything I'd ever ridden to date; although I did feel a bit cramped up, I wrote it off to new geometry and not being on a bike for years. I got on a 54 and WOW, this is how it's supposed to be. Instantly more at ease, no feelings of working against myself for control, night and day difference. This also allowed me to focus more on the aspects of the bikes themselves rather than only which seemed to operate better within my lack of comfort. Ultimately I went with the Madone. They did a basic fitting and all was good for a while. Within a few months I crossed "going to clipless" off my bucket list and had changed saddles twice...I went to a different shop for a fit tweaking. It was minor moves, but the saddle position changed a bit and they dropped and flipped the stem a couple of spacers, along with a swap to a stem an additional 10 in length. Doubting, this was gonna work for me I'm still surprised to say that the old dog still has some hunker down left in him and I'm more comfortable now than I ever would have believed. Trek says it's easier to fit to a smaller frame given a choice if between sizes. I get the point, and most folks today want the smaller frame to look more "pro". Personally, i think it's a better method to ride both and tweak the one that feels the best on a side by side comparison. If that guy hadn't spoke up on that day he saw me go by the window....I'd be on the wrong size, (or at least not the best size), today.