What people are generally looking for when they suggest higher thread counts is a softer, more supple casing. TPI can be an indication of a better tire simply because cheap tires don't pay for more threads. But it is not a reliable measure nor a basis to make a choice. You can get a high thread count by having more layers of thick fabric, or fewer layers of very tightly woven fine threads that also result in a stiffer casing. A moderate thread count of 60 can be far more supple than one at 180 depending on other variables.

The Gatorskin is a decent and fast rolling tire with a rather harsh ride. It feels harsh and crackly in your hand with a moderately stiff tread. Others feel like miniature car tires (to be avoided). A really supple tire feels soft and floppy in both the side walls and the tread, regardless of thread count. This you can feel, in a big way, both in comfort and speed.