I have gradually migrated my 3 road bike tires to Panaracer T-Serv (previously used Panaracer Pasela Tourguard). These are not available in most LBS, so I usually buy online. T-Serv have more puncture resistant tread protection than Pasela Tourguard, but they weigh approximately the same. The two commuter road bikes have T-Serv 700x35, and the Italian classic Ciocc for weekend rides has T-Serv 700-28. I typically put a new T-Serve on the front wheel, and after 5000 miles rotate it to the rear wheel. In most cases, it will last 5000 miles on the rear and then get replaced. The small number of flat tires that I've had while out pedaling on the road in the past 3 years have usually been caused by a nail. No glass or thorn flats in many years.