All of my bikes have fenders in case I get caught by surprise (plus I think they look better and more "complete" that way), but my bespoke wet-weather bike has a singlespeed chainline (currently set up with a Sturmey Archer AW 3-speed hub), a Sturmey Archer XL-FD 90mm drum brake in front, a chainguard, and a waterproof saddle. Also, Schwalbe Marathon tires with reflective sidewalls and puncture protection, for increased visibility and reliability in nasty conditions. I'm currently on the third incarnation of this basic build, the first two having been just singlespeeds, and the very first version started off fixed...and until this current version, they've all had drop bars. The second version was on a different frame, which fit me better but was totaled in a collision.
My main/nice-weather bike (well, now...last year it got ridden through all kinds of nasty weather) is a 2011 Bianchi Volpe with derailleur gearing, a leather Gilles Berthoud saddle, WTB All-Terrain tires, canti brakes (with Kool Stop pads)