Marble is put in there as a tentative overnight stay. I haven't done as much riding as in my younger years, and the last few times i've hit the 40 mile point on a ride, my legs get (what I assume are) severe cramps in the same spot about mid-thigh. My Ireland trip - the two days I went over 40 miles around that 40 mile mark I had to take a break (or three) and do some good stretching.
I am not sure if its because my legs aren't used to doing that sort of mileage, but the first time it happened to me I had to get a ride home and couldn't walk for two days afterwards. The second time it happened I had to abandon my attempt at a LEJOG. The first day of my Ireland tour was 50 miles and sure enough, 40 miles in, my legs started to go. Managed to nurse them back but on my rest day - day 4 - I got a massage that 'hurt so good' when my legs were done.
Also taking into account that I'll probably be fully loaded. So I don't expect to do more then 50 miles in a day, unless half of it is literally downhill.