When I'm riding more than a few miles, I go straight to my largest bike. Masi 3V (oversized tubing means less flexy than non-oversized, which matters in the big sizes) 60.5cm c-c (nominally 62). The larger size (coupled with a mere 3 cm drop saddle to handlebars) puts me in a super-comfy riding position with most of the weight on my butt bones rather than the jewels or the wrists. Oddly, this is also my fastest bike despite being larger and heavier and flexier than others in my fleet. I think that having a bike that fits well makes me able to focus more energy on pedaling and less on adjusting my body to counter pain or pressure.